{"id":2435,"date":"2013-07-01T19:01:32","date_gmt":"2013-07-01T19:01:32","guid":{"rendered":"http:\/\/annmariewayne.com\/?post_type=portfolio&#038;p=2435"},"modified":"2013-07-29T05:02:27","modified_gmt":"2013-07-29T05:02:27","slug":"central-role-of-muc1-in-the-growth-proliferation-and-survival-of-cancer-cells","status":"publish","type":"portfolio","link":"http:\/\/annmariewayne.com\/?portfolio=central-role-of-muc1-in-the-growth-proliferation-and-survival-of-cancer-cells","title":{"rendered":"Central Role of MUC1 in Cancer"},"content":{"rendered":"<div class=\"flex_column av_two_third  flex_column_div first  \" ><p><div  data-size='no scaling'  data-lightbox_size='large'  data-animation='slide'  data-conditional_play=''  data-ids='2419,2418,2682,2683,2688'  data-video_counter='0'  data-autoplay='true'  data-bg_slider='false'  data-slide_height=''  data-handle='av_slideshow'  data-interval='5'  data-class=' '  data-css_id=''  data-scroll_down=''  data-control_layout=''  data-custom_markup=''  data-perma_caption=''  data-autoplay_stopper=''  data-image_attachment=''  data-min_height='0px'  class='avia-slideshow avia-slideshow-1  av-default-height-applied avia-slideshow-no scaling av_slideshow   avia-slide-slider '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><ul class='avia-slideshow-inner ' style='padding-bottom: 56.325301204819%;' ><li  class=' slide-1 ' ><div data-rel='slideshow-1' class='avia-slide-wrap '   ><img src='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/muc1-key-characters.png' width='332' height='187' title='Central Role of MUC1 in Cancer' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class=' slide-2 ' ><div data-rel='slideshow-1' class='avia-slide-wrap '   ><img src='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/muc1-title-screen.png' width='432' height='277' title='muc1-title-screen' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class=' slide-3 ' ><div data-rel='slideshow-1' class='avia-slide-wrap '   ><img src='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/EMD_PWY-pages-portfolio.png' width='1622' height='910' title='EMD_PWY-pages-portfolio' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class=' slide-4 ' ><div data-rel='slideshow-1' class='avia-slide-wrap '   ><img src='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/MUC1-kiosk-portfolio.png' width='1622' height='910' title='MUC1-kiosk-portfolio' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class=' slide-5 ' ><div data-rel='slideshow-1' class='avia-slide-wrap '   ><img src='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/MUC1-lightbox_portfolio2.png' width='1622' height='910' title='MUC1-lightbox_portfolio' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><\/ul><div class='avia-slideshow-arrows avia-slideshow-controls'><a href='#prev' class='prev-slide' aria-hidden='true' data-av_icon='\ue87c' data-av_iconfont='entypo-fontello'>Previous<\/a><a href='#next' class='next-slide' aria-hidden='true' data-av_icon='\ue87d' data-av_iconfont='entypo-fontello'>Next<\/a><\/div><div class='avia-slideshow-dots avia-slideshow-controls'><a href='#1' class='goto-slide active' >1<\/a><a href='#2' class='goto-slide ' >2<\/a><a href='#3' class='goto-slide ' >3<\/a><a href='#4' class='goto-slide ' >4<\/a><a href='#5' class='goto-slide ' >5<\/a><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>MUC1 MOD Animation<\/p>\n<\/div><\/section><br \/>\n<div class='avia-image-container avia_animated_image avia_animate_when_almost_visible top-to-bottom av-styling-    avia-align-center '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><a href='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/CREO_EMDSerono_iPod_video_large.mp4' class='avia_image'  ><img class='avia_image ' src='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/muc1-title-screen.png' alt='' title='muc1-title-screen'  itemprop=\"thumbnailUrl\"  \/><\/a><\/div><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_third  flex_column_div   \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h3    '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Central Role of MUC1 in Cancer<\/h3><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h6><strong>Client: <\/strong>EMD Serono<\/h6>\n<p>This multiphase, multiyear program is composed of a 3-minute 3D animation, pathway booklet with presentation on CD-ROM, backgrounder, interactive panels, booth displays, microsite development, and white paper. Initially, we reviewed EMD Serono materials and strategized with the client team to position the story, design the key characters, and bring a cohesive point of view to engage the medical professional audience. The first phase involved the development of story into the stereoscopic 3D animation and print and interactive materials for US and global exhibits, white paper for education of the EMD Serono and Merck KGaA global teams, and finally distribution worldwide via company-sponsored websites.<\/p>\n<\/div><\/section><br \/>\n<div class=\"togglecontainer   toggle_close_all \" >\n<section class=\"av_toggle_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\"  >    <div class=\"single_toggle\" data-tags=\"{All} \"  >        <p data-fake-id=\"#toggle-id-1\" class=\"toggler activeTitle\"  itemprop=\"headline\"   >Challenge<span class=\"toggle_icon\" >        <span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p>        <div id=\"toggle-id-1-container\" class=\"toggle_wrap active_tc\"  style='display:block;'>            <div class=\"toggle_content invers-color \"  itemprop=\"text\"   ><p>As a result of our successful work on Bone Metastases in Men With Prostate Cancer, we partnered with EMD Serono to bring to life a compelling story about the emerging research of MUC1 as a valid target for immunologic therapies for non-small cell lung cancer. However, many clinicians are not familiar with the intracellular and extracellular functions of MUC1 on epithelial cells and how inappropriate activation of MUC1 in cancer may have an important or central role in the progression of cancer, especially in non-small cell lung cancer, where successful treatment is limited.<\/p>\n            <\/div>        <\/div>    <\/div><\/section>\n<section class=\"av_toggle_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\"  >    <div class=\"single_toggle\" data-tags=\"{All} \"  >        <p data-fake-id=\"#toggle-id-2\" class=\"toggler \"  itemprop=\"headline\"   >Campaign Participation and Development<span class=\"toggle_icon\" >        <span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p>        <div id=\"toggle-id-2-container\" class=\"toggle_wrap \"  >            <div class=\"toggle_content invers-color \"  itemprop=\"text\"   ><p>As Creative Director, I was able to significantly contribute to the crafting of the original story, review our statements against research and provide my own reviews of clinical research, and then to develop the color palette, the design and detail of the key characters, and draft the frames that would make up the key elements of the 3D animation. As with the Bone Metastases campaign, I supervised and directed execution of visuals and mechanicals, worked on strategies with the client team, developed materials and guided the production of the animatic for international market research. I also observed the market research sessions, evaluated and discussed review of the market research and made recommendations to fine tune the content and visuals.<\/p>\n<p>Merck and EMD Serono management commented on how professional and well presented the market research materials were delivered.<\/p>\n<p>My\u00a0 responsibilites include oversight of the deliveries to international as well as US exhibits and creating and managing the MUC1 asset library and brand guidelines for visual and materials.<\/p>\n            <\/div>        <\/div>    <\/div><\/section>\n<\/div><\/p><\/div><\/p>\n<div class=\"flex_column av_two_third  flex_column_div first  \" ><div class='avia-image-container avia_animated_image avia_animate_when_almost_visible top-to-bottom av-styling-    avia-align-center '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/muc1-title-screen-300x192.png' alt='' title=''   itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1' class='avia-section alternate_color avia-section-default avia-shadow avia-bg-style-scroll   container_wrap sidebar_right' style=' '   style=' ' ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-2435'><div class='entry-content-wrapper clearfix'>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h4 style=\"text-align: center;\">Selected Programs and Campaigns<\/h4>\n<\/div><\/section>\n<div  class='hr hr-short hr-center  '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=' grid-sort-container isotope   no_margin-container with-excerpt-container grid-total-even grid-col-4 grid-links-' data-portfolio-id='1'><div data-ajax-id='2535' class=' grid-entry flex_column isotope-item all_sort no_margin post-entry post-entry-2535 grid-entry-overview grid-loop-1 grid-parity-odd  css_sort html_sort photography_sort psd_sort video_sort  av_one_fourth first default_av_fullwidth '><article class='main_color inner-entry'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><a href='http:\/\/annmariewayne.com\/?portfolio=immunology-newsletter-series' title='Immunology Newsletter Series'  data-rel='grid-1' class='grid-image avia-hover-fx'><img width=\"260\" height=\"185\" src=\"http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/Melanoma_feature-260x185.png\" class=\"attachment-portfolio_small size-portfolio_small wp-post-image\" alt=\"\" decoding=\"async\" loading=\"lazy\" \/><\/a><div class='grid-content'><div class='avia-arrow'><\/div><header class=\"entry-content-header\"><h3 class='grid-entry-title entry-title'  itemprop=\"headline\" ><a href='http:\/\/annmariewayne.com\/?portfolio=immunology-newsletter-series' title='Immunology Newsletter Series'>Immunology Newsletter Series<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><\/div><div data-ajax-id='2490' class=' grid-entry flex_column isotope-item all_sort no_margin post-entry post-entry-2490 grid-entry-overview grid-loop-2 grid-parity-even  css_sort html_sort photography_sort psd_sort video_sort  av_one_fourth  default_av_fullwidth '><article class='main_color inner-entry'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><a href='http:\/\/annmariewayne.com\/?portfolio=bone-metastases-in-men-with-prostate-cancer' title='Bone Metastases in Men'  data-rel='grid-1' class='grid-image avia-hover-fx'><img width=\"260\" height=\"185\" src=\"http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/06\/bone-mets_backgrounder-cover-260x185.jpg\" class=\"attachment-portfolio_small size-portfolio_small wp-post-image\" alt=\"\" decoding=\"async\" loading=\"lazy\" \/><\/a><div class='grid-content'><div class='avia-arrow'><\/div><header class=\"entry-content-header\"><h3 class='grid-entry-title entry-title'  itemprop=\"headline\" ><a href='http:\/\/annmariewayne.com\/?portfolio=bone-metastases-in-men-with-prostate-cancer' title='Bone Metastases in Men'>Bone Metastases in Men<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><\/div><div data-ajax-id='2435' class=' grid-entry flex_column isotope-item all_sort no_margin post-entry post-entry-2435 grid-entry-overview grid-loop-3 grid-parity-odd  css_sort html_sort photography_sort psd_sort video_sort  av_one_fourth  default_av_fullwidth '><article class='main_color inner-entry'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><a href='http:\/\/annmariewayne.com\/?portfolio=central-role-of-muc1-in-the-growth-proliferation-and-survival-of-cancer-cells' title='Central Role of MUC1 in Cancer'  data-rel='grid-1' class='grid-image avia-hover-fx'><img width=\"260\" height=\"185\" src=\"http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/muc1-key-characters-260x185.png\" class=\"attachment-portfolio_small size-portfolio_small wp-post-image\" alt=\"\" decoding=\"async\" loading=\"lazy\" \/><\/a><div class='grid-content'><div class='avia-arrow'><\/div><header class=\"entry-content-header\"><h3 class='grid-entry-title entry-title'  itemprop=\"headline\" ><a href='http:\/\/annmariewayne.com\/?portfolio=central-role-of-muc1-in-the-growth-proliferation-and-survival-of-cancer-cells' title='Central Role of MUC1 in Cancer'>Central Role of MUC1 in Cancer<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><\/div><div data-ajax-id='44' class=' grid-entry flex_column isotope-item all_sort no_margin post-entry post-entry-44 grid-entry-overview grid-loop-4 grid-parity-even  post-entry-last  css_sort html_sort photography_sort psd_sort video_sort  av_one_fourth  default_av_fullwidth '><article class='main_color inner-entry'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><a href='http:\/\/annmariewayne.com\/?portfolio=lorem-ipsum' title='Cellular Pathway Booklets'  data-rel='grid-1' class='grid-image avia-hover-fx'><img width=\"260\" height=\"185\" src=\"http:\/\/annmariewayne.com\/wp-content\/uploads\/2013\/07\/TRAIL_featurE-260x185.png\" class=\"attachment-portfolio_small size-portfolio_small wp-post-image\" alt=\"\" decoding=\"async\" loading=\"lazy\" \/><\/a><div class='grid-content'><div class='avia-arrow'><\/div><header class=\"entry-content-header\"><h3 class='grid-entry-title entry-title'  itemprop=\"headline\" ><a href='http:\/\/annmariewayne.com\/?portfolio=lorem-ipsum' title='Cellular Pathway Booklets'>Cellular Pathway Booklets<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><\/div><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_right' style=' '   style=' ' ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-2435'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_half  flex_column_div first  \" 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